: Joints and arthritic conditions are among the most dangerous illnesses that humans have ever encountered and it is even more worrying that there is no recognized treatment for arthritis. The researchers looked for safer alternatives, such as herbal medicines, because the traditional treatments used to treat severe joint inflammatory issues have several negative side effects. A ligand-coated nanomedicine can bind to receptors that are overexpressed by cells in chronically inflammatory tissues, increasing its efficacy and reducing its systemic side effects. This is because the pathophysiology of rheumatoid arthritis suggests that macrophages and overexpressed molecules exist within inflamed tissues, which increases permeability and allows nanomedicines to accumulate in inflamed tissue and cause retention phenomena. The anti-arthritic properties of a variety of plants, their components, extracts, and phyto-isolates have been studied to date. These plant compounds can pose stability and delivery problems, which restricts their efficacy as a treatment for inflammatory diseases. The multifunctional and adaptable features of different nanoparticles can help herbal remedies based on nanotechnology get beyond the delivery constraints of different natural ingredients. The application of nanoformulations in tissue engineering is an additional strategy for delivering drugs directly to bone and cartilage in RA patients. The medication is more therapeutically effective due to nanoformulation's improved synovium and cartilage absorption, accumulation, and penetration at inflammatory joints. Herbal medications with a nanotechnology foundation exhibit superior pharmacokinetic and drug delivery qualities, aid in better oral absorption, regulate drug release, boost in vivo retention capacity, target delivery, and have synergistic effects. This review provides an update on the use of herbal medicines based on nanotechnology, which show promise in treating arthritis and other ailments.

中文翻译：

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基于植物活性的纳米制剂在治疗关节炎中的作用

：关节和关节炎是人类遇到过的最危险的疾病之一，更令人担忧的是关节炎没有公认的治疗方法。研究人员寻找更安全的替代品，例如草药，因为用于治疗严重关节炎症问题的传统疗法有一些负面副作用。配体包被的纳米药物可以与慢性炎症组织中细胞过度表达的受体结合，从而提高其疗效并减少其全身副作用。这是因为类风湿性关节炎的病理生理学表明，巨噬细胞和过度表达的分子存在于发炎组织内，这增加了渗透性，并使纳米药物在发炎组织中积聚并引起滞留现象。迄今为止，人们已经研究了多种植物及其成分、提取物和植物分离物的抗关节炎特性。这些植物化合物可能会带来稳定性和递送问题，从而限制了它们治疗炎症性疾病的功效。不同纳米颗粒的多功能和适应性特征可以帮助基于纳米技术的草药超越不同天然成分的输送限制。纳米制剂在组织工程中的应用是将药物直接输送到 RA 患者骨和软骨的另一种策略。由于纳米制剂改善了炎症关节的滑膜和软骨吸收、积聚和渗透，因此该药物的治疗效果更佳。具有纳米技术基础的草药表现出优异的药代动力学和药物输送质量，有助于更好的口服吸收，调节药物释放，提高体内保留能力，靶向输送，并具有协同效应。这篇综述提供了基于纳米技术的草药使用的最新情况，纳米技术在治疗关节炎和其他疾病方面显示出前景。