This study investigated the protective effect of vanillin against Parkinson’s disease (PD). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg) was administered s.c. for 6 consecutive days to induce PD and mice were treated with vanillin (100 and 200 mg/kg, p.o.) for 15 days. Cognitive, motor and non-motor functions were assessed to evaluate the effect of vanillin in PD mice. Levels of dopamine and glutamate and activity of monoamine oxidaseB (MAO-B) were estimated in vanillin-treated PD mice. The effect of vanillin on the level of lipid peroxidation and superoxide dismutase in brain tissue of PD mice was estimated. Data of the study revealed that vanillin reversed the altered cognitive, motor and non-motor function in PD mice. Activity of MAO-B and neurochemical level were attenuated with vanillin in PD mice. Inflammatory cytokines, nuclear factor kappa B (NF-kB) and Toll-like receptor 4 (TLR-4) levels were lower in the vanillin-treated group compared to the PD group of mice. Data of the study suggest that vanillin protects against neuronal injury and recovers the altered behaviour in PD mice by regulating neurochemical balance and the TLR-4/NF-kB pathway.

中文翻译：

---

香兰素通过调节 TLR-4 炎症通路减轻 MPTP 诱导的帕金森病小鼠的氧化应激和神经化学平衡

这项研究调查了香草醛对帕金森病（PD）的保护作用。连续 6 天皮​​下注射 1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP；30 mg/kg）诱导 PD，并用香草醛（100 和 200 mg/kg，口服）治疗小鼠）15天。通过评估认知、运动和非运动功能来评估香草醛对 PD 小鼠的作用。在香草醛治疗的 PD 小鼠中评估了多巴胺和谷氨酸的水平以及单胺氧化酶 B (MAO-B) 的活性。评估香草醛对PD小鼠脑组织中脂质过氧化和超氧化物歧化酶水平的影响。研究数据显示，香草醛逆转了 PD 小鼠认知、运动和非运动功能的改变。香草醛可减弱 PD 小鼠的 MAO-B 活性和神经化学水平。与 PD 组小鼠相比，香草醛治疗组的炎症细胞因子、核因子 kappa B (NF-kB) 和 Toll 样受体 4 (TLR-4) 水平较低。研究数据表明，香草醛通过调节神经化学平衡和 TLR-4/NF-kB 通路，防止 PD 小鼠的神经元损伤并恢复改变的行为。