BackgroundThe study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE).MethodThe databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software.ResultsA total of five literature studies were included, involving 14,001 participants. Meta-analysis demonstrated that prothrombin A19911G polymorphism increased the risk of VTE (G vs A: OR = 1.17, 95% CI = 1.11–1.22, p < .00001; GG + AG vs AA: OR = 1.22, 95% CI = 1.13–1.31, p < .00001; GG vs AG + AA: OR = 1.23, 95% CI = 1.14–1.33, p < .00001; AG vs AA: OR = 1.15, 95% CI = 1.06–1.25, p = .0006; GG vs AA: OR = 1.34, 95% CI = 1.22–1.48, p < .00001).ConclusionThe polymorphism of prothrombin A19911G enhances the susceptibility to VTE.

中文翻译：

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凝血酶原 A19911G 单核苷酸多态性与静脉血栓栓塞风险的关联：系统评价和荟萃分析

背景本研究采用荟萃分析来全面综合关于凝血酶原 A19911G 多态性与静脉血栓栓塞 (VTE) 风险之间关联的证据。方法检索数据库以识别调查凝血酶原 A19911G 多态性与静脉血栓栓塞 (VTE) 风险之间关联的研究。静脉血栓栓塞。采用Stata 14.0软件进行Meta分析。结果共纳入5篇文献研究，涉及14,001名受试者。荟萃分析表明，凝血酶原 A19911G 多态性增加 VTE 风险（G vs A：OR = 1.17，95% CI = 1.11–1.22，p < .00001；GG + AG vs AA：OR = 1.22，95% CI = 1.13 –1.31，p < .00001；GG 与 AG + AA：OR = 1.23，95% CI = 1.14–1.33，p < .00001；AG 与 AA：OR = 1.15，95% CI = 1.06–1.25，p = . 0006；GG 与 AA：OR = 1.34，95% CI = 1.22–1.48，p < .00001）。结论凝血酶原 A19911G 的多态性增强了 VTE 的易感性。