High sucrose intake is linked to cardiovascular disease, a major global cause of mortality worldwide. Calcium mishandling and inflammation play crucial roles in cardiac disease pathophysiology. Evaluate if sucrose-induced obesity is related to deterioration of myocardial function due to alterations in the calcium-handling proteins in association with proinflammatory cytokines. Wistar rats were divided into control and sucrose groups. Over eight weeks, Sucrose group received 30% sucrose water. Cardiac function was determined using echocardiography and using papillary muscle assay. Western blotting was used to detect calcium handling protein; ELISA assay was used to assess TNF-α and IL-6 levels. Sucrose led to cardiac dysfunction. RYR2, SERCA2, NCX, pPBL Ser16 and L-type calcium channels were unchanged. However, pPBL-Thr17, and TNF-α levels were elevated in the S group. Sucrose induced cardiac dysfunction and decreased myocardial contractility in association with altered pPBL-Thr17 and elevated cardiac pro-inflammatory TNF-α.

中文翻译：

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蔗糖喂养大鼠的心脏功能障碍与受磷蛋白磷酸化和 TNF-α 水平的改变有关

高蔗糖摄入量与心血管疾病有关，心血管疾病是全球死亡的主要原因。钙处理不当和炎症在心脏病病理生理学中起着至关重要的作用。评估蔗糖引起的肥胖是否与由于钙处理蛋白与促炎细胞因子相关的改变而导致的心肌功能恶化有关。 Wistar大鼠被分为对照组和蔗糖组。八周内，蔗糖组接受了 30% 的蔗糖水。使用超声心动图和乳头肌测定来确定心脏功能。 Western blotting用于检测钙处理蛋白； ELISA 测定用于评估 TNF-α 和 IL-6 水平。蔗糖导致心脏功能障碍。 RYR2、SERCA2、NCX、pPBL Ser16 和 L 型钙通道未发生变化。然而，S 组中 pPBL-Thr17 和 TNF-α 水平升高。蔗糖诱导心脏功能障碍并降低心肌收缩力，这与 pPBL-Thr17 的改变和心脏促炎性 TNF-α 的升高有关。