Maxillary sinus squamous cell carcinoma (MS-SCC) is an infrequent malignancy, and determining the optimal neck management for patients with cT3/4N0 MS-SCC remains a topic of ongoing debate. The purpose of this study was to compare the prognoses and quality of life outcomes of patients who underwent either elective neck dissection (END) or elective neck irradiation (ENI) for cT3/4N0 MS-SCC. In this retrospective study, we enrolled patients with surgically treated cT3/4N0 MS-SCC, and the impact of different neck management strategies on regional control and disease-specific survival was compared using propensity score matching. The effect of surgical intervention on quality of life was evaluated using the Mann-Whitney U test. Of the 120 patients included, 36 underwent END. After propensity score matching, our analysis indicated that END did not lead to superior outcomes than ENI, as demonstrated by comparable rates of regional control (p = 0.990) and disease-specific survival (p = 0.999). However, in the 70 returned questionnaires, patients who underwent END reported higher scores in the domains of appearance, chewing, and speech than did patients who underwent ENI. Our findings suggest that while END and ENI contribute to similar prognoses, END yields superior functional outcomes.

中文翻译：

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cT3/4N0 上颌窦鳞状细胞癌的选择性颈清扫术与选择性颈部照射：倾向评分匹配分析

上颌窦鳞状细胞癌 (MS-SCC) 是一种罕见的恶性肿瘤，确定 cT3/4N0 MS-SCC 患者的最佳颈部治疗方案仍然是一个持续争论的话题。本研究的目的是比较接受选择性颈清扫术 (END) 或选择性颈部照射 (ENI) 治疗 cT3/4N0 MS-SCC 的患者的预后和生活质量。在这项回顾性研究中，我们纳入了接受手术治疗的 cT3/4N0 MS-SCC 患者，并使用倾向评分匹配比较了不同颈部管理策略对区域控制和疾病特异性生存的影响。使用曼-惠特尼 U 检验评估手术干预对生活质量的影响。在纳入的 120 名患者中，36 名接受了 END。倾向评分匹配后，我们的分析表明，END 并没有比 ENI 带来更好的结果，区域控制率 (p = 0.990) 和疾病特异性生存率 (p = 0.999) 的可比率证明了这一点。然而，在 70 份回收的问卷中，接受 END 的患者在外观、咀嚼和言语方面的得分高于接受 ENI 的患者。我们的研究结果表明，虽然 END 和 ENI 有助于相似的预后，但 END 产生更好的功能结果。