Abstract

Research into the processes of tissue regeneration in the postcold period is currently in demand in connection with the development of the Arctic, which is characterized by extremely low temperatures. Metabolic or hormonal abnormalities based on insulin resistance and compensatory hyperinsulinemia, which can promote cardiovascular diseases and, consequently, lead to microcirculatory disorders, are aggravating factors that increase the consequences of cold injuries. In this work, we studied the processes of degradation and synthesis of the dermal intercellular matrix, as well as the concentration of sialic acids in the blood serum after local third-degree cold injury. It was revealed that the regenerative process after local cold damage began on the third day and was characterized by increased content of dermal collagen and thickness of collagen fibers. Regeneration against the background of metabolic syndrome was accompanied by a slowdown in tissue repair processes. The recovery process was accompanied with changed content of sialic acids in the blood serum. A distinctive feature of the dynamics of this indicator was enhanced concentration of sialic acids with metabolic disorders on the seventh day and a slow slight decrease throughout the experiment, which reached control values by the 21st day.

中文翻译：

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代谢综合征背景下局部冷伤大鼠真皮细胞间质的降解与合成强度

摘要

目前，随着北极地区气温极低的发展，需要对后寒冷时期的组织再生过程进行研究。基于胰岛素抵抗和代偿性高胰岛素血症的代谢或激素异常可促进心血管疾病，从而导致微循环障碍，是增加冷损伤后果的加重因素。在这项工作中，我们研究了局部三度冷损伤后真皮细胞间基质的降解和合成过程以及血清中唾液酸的浓度。研究表明，局部冷损伤后的再生过程从第三天开始，其特点是真皮胶原蛋白含量和胶原纤维厚度增加。代谢综合征背景下的再生伴随着组织修复过程的减慢。恢复过程伴随着血清中唾液酸含量的变化。该指标动态的一个显着特征是第七天代谢紊乱时唾液酸浓度增加，并在整个实验过程中缓慢略有下降，到第 21 天达到对照值。