Abstract

Premature birth has an obvious effect on all the systems of the body, including the cardiovascular system, which undergoes significant adaptive changes in the early postnatal period of ontogenesis. A comprehensive understanding of the consequences of preterm birth is necessary to ensure early prevention, identification, and treatment of the long-term adverse health consequences of this effect. The purpose of this study was to evaluate the effect of premature birth on the structure of the wall of the ascending aorta in rats. The paper presents the results of a histological and morphometric analysis of the wall of the ascending aorta of Wistar rats born on days 21 and 21.5 of pregnancy (the full gestation period is 22 days). In the wall of the ascending aorta of prematurely born rats, signs of elastolysis and a violation of the parallel arrangement of elastic laminae were found. It has been shown that premature birth results in a decreased specific volume of elastic fibers and increased collagen fibers in the tunica media of the wall of the ascending aorta of prematurely born rats.

中文翻译：

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早产大鼠升主动脉壁的结构特征

摘要

早产对身体各系统都有明显的影响，其中心血管系统在出生后早期个体发生阶段发生了显着的适应性变化。有必要全面了解早产的后果，以确保及早预防、识别和治疗这种影响造成的长期不良健康后果。本研究的目的是评估早产对大鼠升主动脉壁结构的影响。本文介绍了对妊娠第 21 天和 21.5 天（完整妊娠期为 22 天）出生的 Wistar 大鼠升主动脉壁进行组织学和形态测量分析的结果。在早产大鼠的升主动脉壁中，发现了弹性组织溶解的迹象和弹性层平行排列的破坏。研究表明，早产会导致早产大鼠升主动脉壁中膜的弹性纤维比容减少，胶原纤维增加。