Abstract

Surfactant proteins SP-A and SP-D, members of the type C collagen-containing lectin family, are used as diagnostic and prognostic markers for many acute and chronic diseases of the bronchopulmonary system. The aim of the study was to assess the influence of conventional risk factors for chronic noncommunicable diseases on the level of surfactant proteins SP-A and SP-D through a system-structural analysis based on current publications from international databases and official WHO reports. Based on the results of the analytical review, it is concluded that widespread expression of SP-A and SP-D have been documented in numerous studies, and, although the lung remains the main site of the synthesis of surfactant protein, they can be expected to have a significant influence on the immune and inflammatory response in many organs and tissues. The authors note that a number of extrapulmonary effects of these proteins are known. However, many mechanisms of additional cellular effects of SP-A and SP-D outside the bronchopulmonary system still remain unexplored, which indicates the promise of further research in this area.

中文翻译：

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表面活性剂蛋白 SP-A 和 SP-D 以及人类慢性非传染性疾病的常规危险因素

摘要

表面活性蛋白 SP-A 和 SP-D 是含有 C 型胶原的凝集素家族的成员，可用作支气管肺系统许多急性和慢性疾病的诊断和预后标志物。该研究的目的是通过基于国际数据库当前出版物和世界卫生组织官方报告的系统结构分析，评估慢性非传染性疾病的传统危险因素对表面活性蛋白 SP-A 和 SP-D 水平的影响。根据分析审查的结果，得出的结论是，大量研究已记录了 SP-A 和 SP-D 的广泛表达，并且，尽管肺仍然是表面活性蛋白合成的主要部位，但可以预期它们对许多器官和组织的免疫和炎症反应产生重大影响。作者指出，这些蛋白质的许多肺外效应是已知的。然而，SP-A 和 SP-D 在支气管肺系统外的许多额外细胞作用机制仍未被探索，这表明该领域进一步研究的希望。