Understanding deracemization is crucial for progress in chiral chemistry, especially for improving separation techniques. Here, we first report the phenomenon of chiral flipping (or reverse deracemization) in a chiral material (i.e., sodium chlorate crystals) during Viedma deracemization, employing a small-volume reactor system for precise analysis. We observe considerable chiral flipping, influenced by the initial imbalance in the numbers of L- and D-form particles. We developed a simple probabilistic model to further elucidate this behavior. We find that the fluctuation in the populations of chiral crystal particles resulting from their random dissolution and regeneration is the key factor behind chiral flipping. This study not only brings to light this intriguing observation of chiral flipping but also contributes to the enhancement of deracemization techniques.

中文翻译：

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别德马去消旋化中的手性翻转

了解去消旋作用对于手性化学的进展至关重要，特别是对于改进分离技术。在这里，我们首先报道了别德马去外消旋化过程中手性材料（即氯酸钠晶体）的手性翻转（或反向去外消旋化）现象，采用小体积反应器系统进行精确分析。我们观察到相当多的手性翻转，这是受到 L 型和 D 型粒子数量初始不平衡的影响。我们开发了一个简单的概率模型来进一步阐明这种行为。我们发现，手性晶体颗粒的随机溶解和再生导致的种群波动是手性翻转背后的关键因素。这项研究不仅揭示了手性翻转这一有趣的观察结果，而且还有助于增强去消旋化技术。