Dietary methionine restriction (MR) is associated with a spectrum of health‐promoting benefits. Being conducive to prevention of chronic diseases and extension of life span, MR can activate integrated responses at metabolic, transcriptional, and physiological levels. However, how the mitochondria of MR influence metabolic phenotypes remains elusive. Here, we provide a summary of cellular functions of methionine metabolism and an overview of the current understanding of effector mechanisms of MR, with a focus on the aspect of mitochondria‐mediated responses. We propose that mitochondria can sense and respond to MR through a modulatory role of lipoylation, a mitochondrial protein modification sensitized by MR.

中文翻译：

---

脂酰化在线粒体适应蛋氨酸限制中的作用

饮食蛋氨酸限制 (MR) 与一系列促进健康的益处相关。 MR可以激活代谢、转录和生理水平的综合反应，有利于预防慢性疾病和延长寿命。然而，MR 线粒体如何影响代谢表型仍不清楚。在这里，我们总结了蛋氨酸代谢的细胞功能，并概述了目前对 MR 效应机制的理解，重点关注线粒体介导的反应方面。我们认为线粒体可以通过脂酰化（MR 敏感的线粒体蛋白修饰）的调节作用来感知和响应 MR。