Described is a new synthetic route to bis(2‐hydroxy‐3,5‐di‐t‐butylphenyl)methanone and its derivatives. The combined esterification/photo‐Fries rearrangement approach enables a modular preparation of keto‐bridged polyphenols. This protecting group‐free process is highly atom‐ and step‐economic, and a scalable production was easily achieved in the continuous‐flow mode.

中文翻译：

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通过流式光炸薯条重排获得酮桥多酚的简洁路线

描述了双(2-羟基-3,5-二叔丁基苯基)甲酮及其衍生物的新合成路线。酯化/光弗赖斯重排相结合的方法可以实现酮桥多酚的模块化制备。这种无保护基的工艺具有高度的原子经济性和步骤经济性，并且在连续流模式下很容易实现规模化生产。