For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90‐minute extraction duration and a 55°C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, 1H‐NMR, 13C‐NMR, and mass analysis. The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress‐mitigating characteristics, ranging from 71.51 to 81.48%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC50 values of 46.76–81.45 μg/ml). The isolates need to be taken into account as dual COX‐2/5‐LOX antagonists because they also showed a selective anti‐inflammatory effect

中文翻译：

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揭示通过多元提取技术从辣椒种子中分离出的新型香豆素的生物医学应用

动力学热磁萃取是这项工作中首次提出的一种新颖方法。它需要应用四个不同的变量：转速（50、75 和 100 rpm）、磁场（0.8、1.2 和 1.6 T）、时间间隔（30、60 和 90 分钟）和温度（45、 55 和 65°C）。根据植物化学分析，在收集的 81 种青甜椒种子的粗氯仿提取物中检测到多种植物化学类别。发现九种提取物与香豆素化学类别相关，并且具有相同的两个提取参数：90 分钟的提取时间和 55°C 的提取温度。为了能够对它们的香豆素含量进行化学分离和色谱纯化，选择了其中两种含有香豆素的提取物。四种新的植物香豆素已被鉴定，并通过 FTIR 光谱、1H-NMR、13C-NMR 和质量分析区分了它们的分子结构。结果表明，与阳性对照相比，提取的植物香豆素具有出色的氧化应激缓解特性，范围为 71.51% 至 81.48%。此外，它们对测试的恶性群体表现出优异的细胞毒性（IC50值为46.76–81.45 μg/ml）。这些分离株需要被视为双重 COX-2/5-LOX 拮抗剂，因为它们还表现出选择性抗炎作用