In certain neurological disorders such as stroke, the impairment of upper limb function significantly impacts daily life quality and necessitates enhanced neurological control. This poses a formidable challenge in the realm of rehabilitation due to its intricate nature. Moreover, the plasticity of muscle synergy proves advantageous in assessing the enhancement of motor function among stroke patients pre and post rehabilitation training intervention, owing to the modular control strategy of central nervous system. It also facilitates the investigation of long-term alterations in remodeling of muscle functional performance among patients undergoing clinical rehabilitation, aiming to establish correlations between changes in muscle synergies and stroke characteristics such as type, stage, and sites. In this study, a three-week rehabilitation monitoring experiment was conducted to assess the motor function of stroke patients at different stages of rehabilitation based on muscle synergy performance. Additionally, we aimed to investigate the correlation between clinical scale scores, rehabilitation stages, and synergy performance in order to provide a more comprehensive understanding of stroke patient recovery. The results of 7 healthy controls and 16 stroke patients showed that high-functioning patients were superior to low-functioning patients in terms of motor function plasticity towards healthy individuals. Moreover, there was a high positive correlation between muscle synergies and clinical scale scores in high-functioning patients, and the significance gradually emerged with treatment, highlighting the potential of muscle synergy plasticity as a valuable tool for monitoring rehabilitation progress. The potential of this study was also demonstrated for elucidating the physiological mechanisms underlying motor function reconstruction within the central nervous system, which is expected to promote the further application of muscle synergy in clinical assessment.

中文翻译：

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中风后运动功能恢复中的肌肉协同可塑性

在某些神经系统疾病（例如中风）中，上肢功能受损会显着影响日常生活质量，因此需要加强神经系统控制。由于其复杂性，这对康复领域提出了巨大的挑战。此外，由于中枢神经系统的模块化控制策略，肌肉协同的可塑性在评估中风患者康复训练干预前后运动功能的增强方面具有优势。它还有助于研究接受临床康复的患者肌肉功能表现重塑的长期变化，旨在建立肌肉协同作用变化与中风特征（如类型、阶段和部位）之间的相关性。本研究进行了为期三周的康复监测实验，根据肌肉协同表现来评估中风患者在不同康复阶段的运动功能。此外，我们的目的是调查临床量表评分、康复阶段和协同表现之间的相关性，以便更全面地了解中风患者的康复情况。 7名健康对照者和16名中风患者的结果表明，高功能患者在运动功能可塑性方面优于健康个体，优于低功能患者。此外，高功能患者的肌肉协同作用与临床量表评分之间存在高度正相关，并且随着治疗的进行，其重要性逐渐显现，凸显了肌肉协同可塑性作为监测康复进展的有价值工具的潜力。这项研究还证明了阐明中枢神经系统内运动功能重建的生理机制的潜力，有望促进肌肉协同在临床评估中的进一步应用。