Controlled drug release (CDR) is a significant field of research in medical sciences due to its numerous clinical advantages over traditional methods. Encapsulation of a drug in a polymeric matrix is common technique to achieve CDR. In this study, drug‐polymer particles are prepared using poly(lactic‐co‐glycolic acid) (PLGA) as the polymer and curcumin (CUR) as model drug. Two different methods, electrospray and nanoprecipitation, are used to prepare the particles, and optimal samples in each process are selected based on size and polydispersity index (PDI). Samples are characterized using various tests, and entrapment efficiency (EE%) and drug loading (DL%) are calculated using UV spectroscopy. The results showed that nanoprecipitated and electrosprayed PLGA particles successfully encapsulated CUR, with higher encapsulation efficiency (93.2%) and loading capacity (7.2%) for electrosprayed particles. The in vitro drug release showed that electrospray particles have a slower release rate due to higher encapsulation efficiency. The electrospray method turned out to be more viable for synthesizing these polymer‐drug particles due to smaller particle size, lower PDI, higher entrapment efficiency, and drug loading percentage. Finally, the antibacterial behavior of the particles proved that prepared particles provide excellent antibacterial efficacy (99.9%) and can be used as drug delivery systems.

中文翻译：

---

姜黄素包封的聚乳酸-乙醇酸纳米颗粒：通过电喷雾和纳米沉淀制备的颗粒的药物释放动力学比较

药物控制释放（CDR）由于其相对于传统方法的众多临床优势，成为医学科学研究的一个重要领域。将药物封装在聚合物基质中是实现 CDR 的常用技术。在这项研究中，药物聚合物颗粒是用聚乳酸制备的共‐乙醇酸）（PLGA）作为聚合物，姜黄素（CUR）作为模型药物。使用电喷雾和纳米沉淀两种不同的方法来制备颗粒，并根据尺寸和多分散指数（PDI）选择每个过程中的最佳样品。使用各种测试对样品进行表征，并使用紫外光谱计算包封率 (EE%) 和载药量 (DL%)。结果表明，纳米沉淀和电喷雾PLGA颗粒成功包封CUR，电喷雾颗粒具有更高的包封率（93.2%）和负载量（7.2%）。体外药物释放表明，电喷雾颗粒由于较高的包封率而具有较慢的释放速率。事实证明，电喷雾方法更适合合成这些聚合物药物颗粒，因为它具有更小的粒径、更低的 PDI、更高的包封效率和载药百分比。最后，颗粒的抗菌行为证明所制备的颗粒具有优异的抗菌功效（99.9%），可用作药物递送系统。