Although it is well‐known that the Lewis acidity of Metal‐Organic Frameworks (MOFs) can effectively enhance their catalytic activity in organic transformations, access to these Lewis‐acidic sites remains a key hurdle to widespread applications of Lewis‐acidic catalysis by MOFs. Easy accessibility of strong Lewis acidic sites onto 2D MOFs by using proper activation methods can be a cornerstone in attaining desired catalytic performance. Herein, we report a new 2D chemically stable MOF, IITKGP‐60, which displayed excellent framework robustness over a wide pH range (2‐12). Benefiting from the abundant open metal sites (OMSs) and framework robustness, the catalytic activity of the developed material was explored in one‐pot three‐component Strecker reaction and Knoevenagel condensation reaction. Moreover, the developed catalyst is superior in catalyzing the reactions involving sterically hindered substrate (1‐naphthaldehyde) with high turnover numbers. A comparative catalytic study was conducted using different activation methods (chloroform and methanol exchanged activated samples), highlighting the significant effect of activation methods on its catalytic performances. The sustainable synthetic pathway under solvent‐free conditions for a broad scope of substrates using low catalyst loading and excellent recyclability made the developed pH‐stable framework a promising heterogeneous catalyst.

中文翻译：

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通过改变激活方法改变二维 pH 稳定 MOF 的催化效率

尽管众所周知，金属有机框架（MOF）的路易斯酸性可以有效增强其在有机转化中的催化活性，但获得这些路易斯酸性位点仍然是MOF广泛应用路易斯酸性催化的关键障碍。通过使用适当的活化方法，在 2D MOF 上轻松获得强路易斯酸性位点可以成为获得所需催化性能的基石。在此，我们报告了一种新的二维化学稳定的 MOF，IITKGP-60，它在较宽的 pH 范围 (2-12) 内表现出优异的框架稳健性。受益于丰富的开放金属位点（OMS）和骨架稳健性，所开发材料的催化活性在一锅三组分Strecker反应和Knoevenagel缩合反应中得到了探索。此外，所开发的催化剂在催化涉及高周转数的空间位阻底物（1-萘醛）的反应方面具有优越性。采用不同的活化方法（氯仿和甲醇交换活化样品）进行了催化对比研究，强调了活化方法对其催化性能的显着影响。在无溶剂条件下，适用于多种底物的可持续合成途径，使用低催化剂负载量和优异的可回收性，使得所开发的pH稳定框架成为一种有前途的多相催化剂。