Mango (Mangifera indica) has been one of the most cultivated fruits in Thailand and other South and Southeast Asian countries. ‘Bao’ mango is a distinct petite mango variety that is available all year round. This study aimed to investigate the antioxidant and anti‐breast cancer activities of Bao‐mango peel extract (MPE). The total phenolic content (TPC) of MPE was 280.57 ± 7.95 mg quercetin per g of powder. Based on antioxidant activity analyses, MPE had IC50 values of 35.09 and 23.80 ± 0.48 mg/mL for 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azino‐bis‐3‐ethylbenzthiazoline‐6‐sulphonic acid (ABTS) radical scavenging activities, respectively. Additionally, MPE exerted an inhibitory action against MDA‐MB‐231 breast cancer cells with an IC50 of 39.08 ± 5.22 mg/mL. Furthermore, nanoencapsules loaded with MPE using chitosan‐coated poly lactic‐co‐glycolic acid (CS‐PLGA‐(MPE)) were also prepared. It exhibited spherical morphology with an average size of 251.90 ± 19.61 nm. Encapsulation efficiency (EE) of nanoparticles was 30.48%. Moreover, the CS‐PLGA‐(MPE) exhibited higher anticancer activity by affecting cell viability and inhibiting the cell migration and invasion of MDA‐MB‐231 breast cancer cells, compared to the free MPE. Therefore, these findings indicated that MPE and CS‐PLGA‐(MPE) nanoparticles could be promising alternatives to chemicals used for breast cancer treatment.

中文翻译：

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'宝'芒果（Mangifera indica）皮乙醇提取物及其纳米胶囊对三阴性乳腺癌细胞系的抗癌活性

芒果（Mangifera indica）一直是泰国和其他南亚和东南亚国家种植最多的水果之一。 “Bao”芒果是一种独特的娇小芒果品种，全年供应。本研究旨在探讨包芒果皮提取物（MPE）的抗氧化和抗乳腺癌活性。 MPE 的总酚含量 (TPC) 为每克粉末 280.57 ± 7.95 毫克槲皮素。根据抗氧化活性分析，MPE 对 1,1-二苯基-2-三硝基苯肼 (DPPH) 和 2,2'-连氮基-双-3-乙基苯并噻唑啉-6-磺酸的 IC50 值为 35.09 和 23.80 ± 0.48 mg/mL （ABTS）自由基清除活性，分别。此外，MPE 对 MDA-MB-231 乳腺癌细胞具有抑制作用，IC50 为 39.08 ± 5.22 mg/mL。此外，还使用壳聚糖包被的聚乳酸-乙醇酸共聚物（CS-PLGA-（MPE））制备了负载 MPE 的纳米胶囊。它呈现球形形态，平均尺寸为251.90±19.61 nm。纳米粒子的封装效率(EE)为30.48%。此外，与游离MPE相比，CS-PLGA-(MPE)通过影响细胞活力并抑制MDA-MB-231乳腺癌细胞的细胞迁移和侵袭而表现出更高的抗癌活性。因此，这些发现表明 MPE 和 CS-PLGA-(MPE) 纳米颗粒可能成为用于乳腺癌治疗的化学品的有希望的替代品。