Schizophrenia is accompanied by aberrant interactions of intrinsic brain networks. However, the modulatory effect of electroencephalography (EEG) rhythms on the functional connectivity (FC) in schizophrenia remains unclear. This study aims to provide new insight into network communication in schizophrenia by integrating FC and EEG rhythm information. After collecting simultaneous resting-state EEG-functional magnetic resonance imaging data, the effect of rhythm modulations on FC was explored using what we term “dynamic rhythm information.” We also investigated the synergistic relationships among three networks under rhythm modulation conditions, where this relationship presents the coupling between two brain networks with other networks as the center by the rhythm modulation. This study found FC between the thalamus and cortical network regions was rhythm-specific. Further, the effects of the thalamus on the default mode network (DMN) and salience network (SN) were less similar under alpha rhythm modulation in schizophrenia patients than in controls ($meanScZ:meanHC=0.715:0.777$). However, the similarity between the effects of the central executive network (CEN) on the DMN and SN under gamma modulation was greater ($meanScZ:meanHC=0.695:0.629$), and the degree of coupling was negatively correlated with the duration of disease ($r=-0.373$, $p=0.003$). Moreover, schizophrenia patients exhibited less coupling with the thalamus as the center and greater coupling with the CEN as the center. These results indicate that modulations in dynamic rhythms might contribute to the disordered functional interactions seen in schizophrenia.

精神分裂症伴随着内在大脑网络的异常相互作用。然而，脑电图（EEG）节律对精神分裂症功能连接（FC）的调节作用仍不清楚。本研究旨在通过整合 FC 和 EEG 节律信息，为精神分裂症的网络交流提供新的见解。在收集同步静息态脑电图功能磁共振成像数据后，使用我们所说的“动态节律信息”探讨了节律调制对 FC 的影响。我们还研究了节律调制条件下三个网络之间的协同关系，这种关系代表了两个大脑网络之间通过节律调制以其他网络为中心的耦合。这项研究发现丘脑和皮质网络区域之间的 FC 具有节律特异性。此外，精神分裂症患者在α节律调节下丘脑对默认模式网络（DMN）和显着网络（SN）的影响与对照组相比不太相似。$米eAnSCZ：米eAnHC=0。715：0。777$）。然而，在伽玛调制下，中央执行网络（CEN）对 DMN 和 SN 的影响之间的相似性更大（$米eAnSCZ：米eAnHC=0。695：0。629$），耦合程度与病程呈负相关（$r=-0。373$,$p=0。003$）。此外，精神分裂症患者以丘脑为中心的耦合度较低，而以CEN为中心的耦合度较高。这些结果表明，动态节律的调节可能导致精神分裂症中出现的功能相互作用紊乱。