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Polymorphism rs3733591 of the SLC2A9 gene and metabolic syndrome affect gout risk in Taiwan Biobank subjects
Frontiers in Genetics ( IF 3.7 ) Pub Date : 2024-04-16 , DOI: 10.3389/fgene.2024.1374405 Chun-Nan Lin , Chien-Chang Ho , Pao-Chun Hsieh , Chih-Hsuan Hsiao , Oswald Ndi Nfor , Yung-Po Liaw
Frontiers in Genetics ( IF 3.7 ) Pub Date : 2024-04-16 , DOI: 10.3389/fgene.2024.1374405 Chun-Nan Lin , Chien-Chang Ho , Pao-Chun Hsieh , Chih-Hsuan Hsiao , Oswald Ndi Nfor , Yung-Po Liaw
Background:Over the past few decades, gout and diseases like metabolic syndrome (MetS) have become more prevalent. Attempts have been made in Taiwan to identify the genes responsible for gout. A few gene loci, among them SLC2A9 , have been identified using Taiwan Biobank (TWB) data. We, therefore, examined whether MetS could also account for the association between polymorphism SLC2A9 rs3733591 and gout.Methods:The final analysis consisted of 73,558 subjects, of whom 2,709 had gout. To estimate the likelihood of gout occurrence based on rs3733591 and MetS, we used logistic regression models.Results:Rs3733591-TC + CC compared to TT genotype was associated with gout (OR, 1.15; 95% CI, 1.06–1.25). Also associated with gout was MetS (OR, 1.21; 95% CI, 1.10–1.33). A significant interaction was seen between rs3733591 and MetS (p -value = 0.039). Using rs3733591-TT/no MetS as the reference group, the ORs (95% CI) for gout was 1.24 (1.11–1.38) for TC + CC/no MetS, 1.35 (1.17–1.56) for TT/MetS, and 1.39 (1.22–1.58) for TC + CC/MetS. However, subgroup analysis defined by sex showed no significant associations in women.Conclusion:In summary, metabolic syndrome and SLC2A9 rs3733591 genotypes were interactively associated with gout in Taiwanese men, but not women.
更新日期：2024-04-16
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