The first and concise syntheses of the anticancer agent diplofuranone A and the fatty acid-derived metabolite diapolic acid A have been demonstrated using easily accessible and commercially available starting materials. The key feature of these syntheses is the efficient diversification of highly stereo- and chemoselectively constructed (E,E)-1,6-dioxo-2,4-dienes using ruthenium catalytic conditions, which enabled straightforward access to diversely substituted bioactive molecules.

中文翻译：

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双氟呋喃酮A和二保酸A的全合成

抗癌剂二氯呋喃酮 A 和脂肪酸衍生的代谢物二保酸 A 的首次简明合成已使用易于获得和市售的起始材料进行了证明。这些合成的关键特征是使用钌催化条件对高度立体和化学选择性构建的 ( E , E )-1,6-二氧代-2,4-二烯进行有效多样化，从而能够直接获得不同取代的生物活性分子。