Chromatin remodeling is a critical step in the DNA damage response, and the ATP-dependent chromatin remodelers are a group of epigenetic regulators that alter nucleosome assembly and regulate transcription factor accessibility to DNA, preventing genomic instability and tumorigenesis caused by DNA damage. The SWI/SNF chromatin remodeling complex is one of them, and mutations in the gene encoding the SWI/SNF subunit are frequently found in digestive tumors. We review the most recent literature on the role of SWI/SNF complexes in digestive tumorigenesis, with different SWI/SNF subunits playing different roles. They regulate the biological behavior of tumor cells, participate in multiple signaling pathways, interact with multiple genes, and have some correlation with the prognosis of patients. Their carcinogenic properties may help discover new therapeutic targets. Understanding the mutations and defects of SWI/SNF complexes, as well as the underlying functional mechanisms, may lead to new strategies for treating the digestive system by targeting relevant genes or modulating the tumor microenvironment.

染色质重塑是 DNA 损伤反应中的关键步骤，ATP 依赖性染色质重塑剂是一组表观遗传调节因子，可改变核小体组装并调节转录因子对 DNA 的可及性，从而防止 DNA 损伤引起的基因组不稳定和肿瘤发生。 SWI/SNF染色质重塑复合体就是其中之一，编码SWI/SNF亚基的基因突变常见于消化道肿瘤中。我们回顾了有关 SWI/SNF 复合物在消化道肿瘤发生中作用的最新文献，不同的 SWI/SNF 亚基发挥着不同的作用。它们调节肿瘤细胞的生物学行为，参与多种信号通路，与多个基因相互作用，与患者的预后有一定的相关性。它们的致癌特性可能有助于发现新的治疗靶点。了解 SWI/SNF 复合物的突变和缺陷以及潜在的功能机制，可能会导致通过靶向相关基因或调节肿瘤微环境来治疗消化系统的新策略。