Neurocognitive decline is one of the foremost dire issues in medicine today. The mechanisms by which dementia pathogenesis ensues are complicated and multifactorial, particularly in the case of Alzheimer’s disease (AD). One irrefutable, yet unexplained factor is the gender disparity in AD, in which women are disproportionately affected by AD, both in the rate and severity of the disease. Examining the multifaceted contributing causes along with unique gender dynamics in modifiable risk factors, such as diet, may lend some insight into why this disparity exists and potential paths forward. The aim of this brief narrative review is to summarize the current literature of gender differences in dietary habits and how they may relate to neuroinflammatory states that contribute to AD pathogenesis. As such, the interplay between diet, hormones, and inflammation will be discussed, along with potential interventions to inform care practices.

中文翻译：

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饮食习惯、神经炎症和阿尔茨海默病的性别差异之间的关系

神经认知能力下降是当今医学界最严重的问题之一。痴呆症的发病机制是复杂且多因素的，特别是在阿尔茨海默病 (AD) 的情况下。一个无可辩驳但无法解释的因素是 AD 中的性别差异，其中女性受 AD 的影响尤其严重，无论是发病率还是严重程度。检查多方面的成因以及饮食等可改变风险因素中独特的性别动态，可能有助于了解这种差异存在的原因和潜在的前进道路。这篇简短的叙述性综述的目的是总结当前关于饮食习惯性别差异的文献，以及它们如何与导致 AD 发病机制的神经炎症状态相关。因此，将讨论饮食、激素和炎症之间的相互作用，以及为护理实践提供信息的潜在干预措施。