Lipid-Lowering Meroterpenoids Penihemeroterpenoids A–F from Penicillium herquei GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway,Organic Letters

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Lipid-Lowering Meroterpenoids Penihemeroterpenoids A–F from Penicillium herquei GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway
Organic Letters ( IF 5.2 ) Pub Date : 2024-04-17 , DOI: 10.1021/acs.orglett.4c00946
Huimei Deng ₁ , Jingxin He ₁ , Binglin Chang ₁ , Qingcui Li ₁ , Yena Liu ₂ , Zhongxiang Zhao ₁ , Zhongqiu Liu ₁ , Hui Cui ₁

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Penihemeroterpenoids A–C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D–F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C–F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid export gene MTTP.

更新日期：2024-04-17

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