Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions. This includes roles in the regulation of transcription, translation, chromatin maintenance, immune response, and many other processes. This special issue presents the past, present, and future of epitranscriptomics research with a focus on mRNA. It includes perspectives from experts in the field, with the goal of encouraging discussions and debates that will further advance this area of research and enable it to realize its full potential in basic research and applications to human health and disease.

中文翻译：

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mRNA表观转录组学

表观转录组学是指 RNA 中的化学变化，包括具有不同化学计量和功能的多种化学类型。 RNA 修饰在化学上高度多样化，并以细胞类型和细胞状态依赖性方式做出反应，从而能够并促进多种生物功能的执行。这包括转录、翻译、染色质维护、免疫反应和许多其他过程的调节作用。本期特刊介绍了表观转录组学研究的过去、现在和未来，重点是 mRNA。它包含了该领域专家的观点，旨在鼓励讨论和辩论，从而进一步推进该研究领域，并使其在人类健康和疾病的基础研究和应用中充分发挥潜力。