Paediatric acute liver failure (PALF) is a life-threatening disease. Management aims to support hepatic regeneration or to bridge to liver transplantation. High-volume plasmapheresis (HVP) removes protein-bound substances, alleviates inflammation, and improves survival in adult acute liver failure. However, experience with HVP in PALF is limited. Aim of this study is to report on feasibility, safety, efficacy and outcomes of HVP in PALF.

中文翻译：

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大容量血浆置换在小儿急性肝衰竭治疗中的作用。

小儿急性肝衰竭（PALF）是一种危及生命的疾病。管理的目的是支持肝再生或过渡到肝移植。高容量血浆置换 (HVP) 可去除蛋白质结合物质、减轻炎症并提高成人急性​​肝衰竭患者的生存率。然而，PALF 中 HVP 的经验有限。本研究的目的是报告 HVP 在 PALF 中的可行性、安全性、有效性和结果。