Photosensitizer (PS) with enhanced fluorescence is attractive for image-guided photodynamic therapy (PDT) due to its dual functional role in Singlet Oxygen Generation (SOG) and producing high fluorescence signals. Here, Eosin-Y (Ey) decorated polymer coated gold nanorods (GNRs) of different aspect ratios are synthesized and introduced as novel plasmon-enhanced nano-photosensitizers for this purpose. We show, upon excitation at 519 nm, simultaneous enhancement in fluorescence and SOG was achieved for the hybrid nanostructure. The best enhancement factors of 110 and 18 for metal-enhanced fluorescence and metal-enhanced SOG, respectively, are obtained with GNRs of length 133 nm and width 45 nm, where Ey is positioned at 12.6 nm from the metal core using layer-by-layer assembly of oppositely charged polymers. The observed plasmonic effect is critically analysed by comparing the near field damping rate along with decay length, far field scattering and nonradiative energy transfer of the nanohybrids.

中文翻译：

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双功能纳米光敏剂：曙红-Y 修饰的金纳米棒，用于等离子体增强荧光和单线态氧产生

具有增强荧光的光敏剂（PS）由于其在单线态氧生成（SOG）和产生高荧光信号中的双重功能作用，对图像引导光动力疗法（PDT）很有吸引力。在这里，合成了不同纵横比的曙红-Y（Ey）装饰的聚合物涂层金纳米棒（GNR），并将其作为新型等离子体增强纳米光敏剂引入。我们表明，在 519 nm 激发下，混合纳米结构实现了荧光和 SOG 的同时增强。金属增强荧光和金属增强 SOG 的最佳增强因子分别为 110 和 18，是通过长度为 133 nm、宽度为 45 nm 的 GNR 获得的，其中 Ey 使用逐层定位在距离金属核心 12.6 nm 处。带相反电荷的聚合物的层组装。通过比较近场阻尼率以及纳米杂化物的衰减长度、远场散射和非辐射能量转移，对观察到的等离子体效应进行了严格的分析。