Nanozymes have been widely used for treating reactive oxygen species (ROS) caused diseases. However, the ROS-dependent antibacterial property is inevitably damaged during the process of scavenging ROS, which is unfavorable for the treatment of diseases related to both ROS accumulation and bacterial infections. To address the issues, biomedical materials with both ROS-elimination ability and ROS-independent antibacterial capacity are fabricated via in situ depositing spherical Au nanoparticles (Au NPs) on rough surface of metal organic frameworks composed of Ce(III) and terephthalic acid (Ce-BDC@Au MOFs). The synthesized Ce-BDC@Au MOFs showed multi-enzymatic activities owing to the reversible conversion between Ce3+ and Ce4+, and can significantly scavenge ROS in cancer cells. The deposition of spherical Au NPs on surface of Ce-BDC MOFs causes Au NPs to come close proximity for forming plasmon resonance coupling, inducing the resonance wavelength of Au NPs red shifted to NIR region. Based on this, Ce-BDC@Au MOFs show good photothermal conversion efficiency under NIR laser (808 nm) irradiation. Benefitting from rough surface and photothermal conversion ability, Ce-BDC@Au MOFs have high antibacterial efficiency against staphylococcus aureus through both mechanically damaging and photothermal destruction. This strategy is biosafety and effectiveness for treating diseases related to both ROS accumulation and bacterial infections.

中文翻译：

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用于消除ROS和光热灭菌的多功能Ce(III)-对苯二甲酸@Au金属有机框架

纳米酶已广泛用于治疗活性氧（ROS）引起的疾病。然而，在清除ROS的过程中，ROS依赖的抗菌性能不可避免地受到破坏，这不利于治疗与ROS积累和细菌感染相关的疾病。为了解决这个问题，通过在由 Ce(III) 和对苯二甲酸 (Ce) 组成的金属有机框架的粗糙表面上原位沉积球形金纳米粒子 (Au NPs) 来制备兼具 ROS 消除能力和 ROS 独立抗菌能力的生物医学材料。 -BDC@Au MOF)。合成的Ce-BDC@Au MOFs由于Ce3+和Ce4+之间的可逆转化而表现出多酶活性，并且可以显着清除癌细胞中的ROS。 Ce-BDC MOFs 表面沉积球形 Au NPs 导致 Au NPs 靠近形成等离子体共振耦合，导致 Au NPs 的共振波长红移至近红外区域。基于此，Ce-BDC@Au MOFs在近红外激光（808 nm）照射下表现出良好的光热转换效率。得益于粗糙的表面和光热转换能力，Ce-BDC@Au MOFs 通过机械损伤和光热破坏对金黄色葡萄球菌具有较高的抗菌效率。该策略对于治疗与 ROS 积累和细菌感染相关的疾病具有生物安全性和有效性。