Porcine epidemic diarrhea virus (PEDV) causes immensely large economic losses worldwide in the swine industry. PEDV attacks the intestine, disrupts intestinal epithelium morphology and barrier integrity, and results in profound diarrhea and high mortality. A commercially available isotonic protein solution (IPS) (Tonisity Px) has anecdotally been reported to be effective in supportive treatment of piglets with active PEDV infections. This study evaluated the effects of supplementing (or not) the drinking water of 14 day old PEDV-infected piglets with the IPS on the content of E-cadherin, fibronectin, interferon-alpha (IFN-α), and matrix metalloproteinase 9 (MMP-9) in duodenal tissue. The content of PEDV DNA in feces was also measured. Though both groups had similar PEDV shedding at day 1, IPS piglets had significantly lower PEDV shedding at day 5, 14 and 21. The IPS group also had a shorter duration of PEDV virus shedding.

中文翻译：

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等渗蛋白溶液有利于调节猪肠道免疫反应和细胞粘附标记物，并减少体内 PEDV 脱落

猪流行性腹泻病毒（PEDV）给全球养猪业造成了巨大的经济损失。 PEDV 攻击肠道，破坏肠上皮形态和屏障完整性，导致严重腹泻和高死亡率。据报道，市售的等渗蛋白溶液 (IPS) (Tonisity Px) 可有效支持治疗患有活动性 PEDV 感染的仔猪。本研究评估了在感染 PEDV 的 14 日龄仔猪的饮用水中添加（或不添加）IPS 对 E-钙粘蛋白、纤连蛋白、干扰素-α (IFN-α) 和基质金属蛋白酶 9 (MMP) 含量的影响-9) 在十二指肠组织中。还测量了粪便中PEDV DNA的含量。尽管两组仔猪在第 1 天的 PEDV 排毒量相似，但 IPS 仔猪在第 5、14 和 21 天的 PEDV 排毒量显着较低。IPS 组的 PEDV 病毒排毒持续时间也较短。