Cataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract formation, and AD.

中文翻译：

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血液中游离脂肪酸与白蛋白的摩尔比增加是白内障和阿尔茨海默氏病发生的原因和早期生物标志物

白内障和阿尔茨海默病 (AD) 密切相关，并与衰老和全身性疾病相关，这些疾病会增加血液中游离脂肪酸与白蛋白 (mFAR) 的摩尔比。根据我们早期对老年性白内障发展的研究结果以及最近发表的关于阿尔茨海默氏病发病机制的文献结果，我们认为这两种疾病存在共同的脂毒性级联反应，解释了衰老、白内障升高之间的密切联系。血液中的 mFAR、白内障形成和 AD。