We investigated possible associations between the internal concentrations of POPs and correlations between blood and tumor tissue concentrations in patients who underwent surgery for breast cancer and breast reduction as controls. Genetic variations in CYP1A1, GSTP1, GSTM1, and GSTT1 and hOGG1 were evaluated to determine whether they represent risk factors for breast cancer. Certain POPs have been found to be associated with breast cancer development. polymorphism represented a significant risk for breast cancer with unadjusted OR. However, the null polymorphism represented a significant risk for breast cancer when OR adjusted for age and smoking status. polymorphism was a significant risk factor for breast cancer, regardless of whether the OR was adjusted. These results suggest that exposure to certain POPs, and polymorphisms, age, and smoking status are risk factors for breast cancer. In addition, the blood concentrations of some POPs represent surrogates for breast tissue concentrations.

中文翻译：

---

乳腺癌患者血液和组织中持久性有机污染物水平及遗传易感性

我们研究了接受乳腺癌手术和乳房缩小手术作为对照的患者体内持久性有机污染物浓度与血液和肿瘤组织浓度之间的相关性。对 CYP1A1、GSTP1、GSTM1、GSTT1 和 hOGG1 的遗传变异进行了评估，以确定它们是否代表乳腺癌的危险因素。已发现某些持久性有机污染物与乳腺癌的发生有关。多态性代表了未经调整 OR 的乳腺癌的显着风险。然而，当 OR 根据年龄和吸烟状况进行调整时，无效多态性代表了患乳腺癌的显着风险。无论 OR 是否调整，多态性都是乳腺癌的一个重要危险因素。这些结果表明，接触某些持久性有机污染物、多态性、年龄和吸烟状况是乳腺癌的危险因素。此外，一些持久性有机污染物的血液浓度可以替代乳腺组织的浓度。