Guided tissue/bone regeneration (GTR/GBR) is a widely used technique in dentistry to facilitate the regeneration of damaged bone and tissue, which involves guiding materials that eventually degrade, allowing newly created tissue to take its place. This comprehensive review the evolution of biomaterials for guided bone regeneration that showcases a progressive shift from non-resorbable to highly biocompatible and bioactive materials, allowing for more effective and predictable bone regeneration. The evolution of biomaterials for guided bone regeneration GTR/GBR has marked a significant progression in regenerative dentistry and maxillofacial surgery. Biomaterials used in GBR have evolved over time to enhance biocompatibility, bioactivity, and efficacy in promoting bone growth and integration. This review also probes into several promising fabrication techniques like electrospinning and latest 3D printing fabrication techniques, which have shown potential in enhancing tissue and bone regeneration processes. Further, the challenges and future direction of GTR/GBR are explored and discussed.

中文翻译：

---

引导骨再生膜的进展：材料和技术的全面综述

引导组织/骨骼再生（GTR/GBR）是牙科中广泛使用的一种技术，可促进受损骨骼和组织的再生，其中涉及引导材料最终降解，从而使新产生的组织取代其位置。这篇全面回顾了用于引导骨再生的生物材料的演变，展示了从不可吸收材料到高度生物相容性和生物活性材料的逐步转变，从而实现更有效和可预测的骨再生。用于引导骨再生 GTR/GBR 的生物材料的发展标志着再生牙科和颌面外科的重大进展。 GBR 中使用的生物材料随着时间的推移不断发展，以增强生物相容性、生物活性以及促进骨骼生长和整合的功效。本综述还探讨了几种有前景的制造技术，例如静电纺丝和最新的 3D 打印制造技术，这些技术在增强组织和骨骼再生过程方面显示出潜力。此外，还探讨和讨论了 GTR/GBR 的挑战和未来方向。