Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by inducing anti-inflammatory cytokines, promoting regulatory T-cell development, and ultimately favouring a Th2-biased immune response. This systematic review focused on helminth-derived proteins and explored their impact on reducing inflammatory responses in mouse models of colitis. A systematic search across Medline, EMBASE, Web of Science, and Cochrane Library identified fourteen relevant studies. These studies reported immunomodulatory changes, including increased production of anti-inflammatory cells and cytokines. In mouse models of colitis treated with on helminth-derived proteins, significant improvements in pathological parameters such as body weight, colon length, and microscopic inflammatory scores were observed compared to control groups. Moreover, helminth-derived proteins can enhance the function of Tregs and alleviate the severity of inflammatory conditions. The findings underscore the pivotal role of helminth-derived proteins in immunomodulation, specifically in the axis of cytokine secretion and immune cell polarization. The findings offer new opportunities for treating chronic inflammatory conditions such Crohn’s disease.

中文翻译：

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蠕虫衍生蛋白作为免疫系统调节剂：对其缓解结肠炎的前景进行系统评价

蠕虫衍生的蛋白质具有免疫调节特性，影响宿主的免疫反应，作为蠕虫生存的适应性策略。蠕虫衍生的蛋白质通过诱导抗炎细胞因子、促进调节性 T 细胞发育并最终促进偏向 Th2 的免疫反应来调节免疫反应。本系统综述的重点是蠕虫衍生的蛋白质，并探讨了它们对减少结肠炎小鼠模型炎症反应的影响。对 Medline、EMBASE、Web of Science 和 Cochrane 图书馆的系统检索发现了 14 项相关研究。这些研究报告了免疫调节变化，包括抗炎细胞和细胞因子的产生增加。在用蠕虫衍生蛋白治疗的小鼠结肠炎模型中，与对照组相比，观察到体重、结肠长度和微观炎症评分等病理参数显着改善。此外，蠕虫衍生的蛋白质可以增强 Tregs 的功能并减轻炎症的严重程度。这些发现强调了蠕虫衍生蛋白在免疫调节中的关键作用，特别是在细胞因子分泌和免疫细胞极化的轴上。这些发现为治疗克罗恩病等慢性炎症性疾病提供了新的机会。