Due to the various side effects of conventional cancer treatment therapy, efforts to find anticancer agents with minimal side effects are in great demand. One of them is the synthesis of organotin(IV) hydroxybenzoate derivatives. Three organotin(IV) compounds, namely diphenyltin(IV) 2-hydroxybenzoate, [Ph₂Sn(2-HBz)₂] (DPT2-DH) (2), diphenyltin(IV) 3-hydroxybenzoate, [Ph₂Sn(3-HBz)₂] (DPT3-DH) (3) and diphenyltin(IV) 4-hydroxybenzoate, [Ph₂Sn(4-HBz)₂] (DPT4-DH) (4), have been successfully synthesized. Compounds 2–4 were obtained by reacting diphenyltin(IV) oxide, [Ph₂SnO] (DPTO) (1) with 2-hydroxybenzoic acid (2-HHBz), 3-hydroxybenzoic acid (3-HHBz) and 4-hydroxybenzoic acid (4-HHBz), respectively. The compounds synthesized were fully characterized by UV–Vis, FT-IR, and NMR spectroscopies and microelemental analysis to see the purity of the compounds. The antiproliferative activity of the compounds was tested against three cancer cell lines of lung cancer (A549), breast cancer (MCF-7) and cervical cancer (HeLa), and their activities were compared to normal cell cancer, Vero. The results of the antiproliferative test demonstrated that compound 2 was found to be most active against the A549 cell line. Compounds 2 and 3 are active against MCF-7 while compound 4 was found to be least active against all cancer lines tested. All compounds have also been found to have a good selectivity index (SI) toward the A549 cell line, although their SI values are not good enough against the HeLa cell line.

由于传统癌症治疗疗法存在多种副作用，因此迫切需要寻找副作用最小的抗癌药物。其中之一是羟基苯甲酸有机锡(IV)衍生物的合成。三种有机锡(IV)化合物，即二苯基锡(IV) 2-羟基苯甲酸酯、[Ph ₂ Sn(2-HBz) ₂ ] (DPT2-DH) ( 2 )、二苯基锡(IV) 3-羟基苯甲酸酯、[Ph ₂ Sn(3已成功合成了-HBz) ₂ ] (DPT3-DH) ( 3 ) 和4-羟基苯甲酸二苯基锡(IV) , [Ph ₂ Sn(4-HBz) ₂ ] (DPT4-DH) ( 4 )。化合物2 – 4通过氧化二苯基锡(IV)、[Ph ₂ SnO] (DPTO) ( 1 ) 与 2-羟基苯甲酸 (2-HHBz)、3-羟基苯甲酸 (3-HHBz) 和 4-羟基苯甲酸反应获得(4-HHBz)，分别。合成的化合物通过紫外-可见光、傅立叶变换红外光谱、核磁共振波谱和微量元素分析进行​​了全面表征，以了解化合物的纯度。测试了这些化合物针对肺癌（A549）、乳腺癌（MCF-7）和宫颈癌（HeLa）三种癌细胞系的抗增殖活性，并将其活性与正常细胞癌Vero进行了比较。抗增殖试验的结果表明，化合物2对A549细胞系最具活性。化合物2和3对 MCF-7 有活性，而化合物4对所有测试的癌细胞系活性最低。还发现所有化合物对 A549 细胞系都具有良好的选择性指数 (SI)，尽管它们的 SI 值对 HeLa 细胞系不够好。