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The Potential of Lectins and Their Recognized Glycoconjugates in the Human Body
Biology Bulletin Reviews Pub Date : 2024-04-18 , DOI: 10.1134/s2079086424020075
M. V. Lakhtin , V. M. Lakhtin , A. Yu. Mironov , V. A. Aleshkin , S. S. Afanasyev , S. Yu. Kombarova

Abstract

The modern concepts of lectins and glycoconjugates binding to them, the features and patterns of their interaction, and the protective role and potential in the human body are summarized. The analysis of terms and approaches to classifications of lectins is carried out. The features of natural and synthetic glycoconjugates, recognized and bound by lectins, in symbiotic relationships, in innate immunity at the reception level are emphasized. The levels of specificity of lectins are considered. There is a need to expand research on the glycoconjugate specificity of lectins and their systems and to assess the communication potential of glycoconjugates in relation to any protein combinations and systems as lectins. The participation of lectin and glycoconjugate systems in signal transmission and communication is noted. Lectins manifest themselves as basic for superstructure glycoconjugate effectors in soluble and solid cell phases in cascade directed assemblies forming the interactome network. Lectins and glycoconjugates, as inextricably co-functioning, are promising in biology, medicine, and biotechnologies.



中文翻译:

凝集素及其在人体内公认的糖复合物的潜力

摘要

总结了凝集素及其结合糖复合物的现代概念、它们相互作用的特征和模式、以及在人体中的保护作用和潜力。对凝集素的术语和分类方法进行了分析。强调了天然和合成糖复合物的特征,被凝集素识别和结合,在共生关系中,在接收水平的先天免疫中。考虑凝集素的特异性水平。需要扩大对凝集素及其系统的糖缀合物特异性的研究,并评估糖缀合物与任何蛋白质组合和凝集素系统相关的通讯潜力。注意到凝集素和糖缀合物系统参与信号传输和通讯。凝集素本身是可溶性和固体细胞相中形成相互作用组网络的级联定向组装中超结构糖缀合物效应子的基础。凝集素和糖复合物密不可分地协同作用,在生物学、医学和生物技术领域具有广阔的前景。

更新日期:2024-04-18
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