BackgroundEarlier studies showed a negative correlation between life's simple 7 (LS7) and high‐sensitivity C‐reactive protein (hs‐CRP), but no association has been found between life's essential 8 (LE8), an improved version of LS7, and hs‐CRP.HypothesisThis study investigated the association between LE8 and hs‐CRP utilizing data from the National Health and Nutritional Examination Survey.MethodsA total of 7229 adults were incorporated in our study. LE8 was scored according to American Heart Association guidelines, and LE8 was divided into health behaviors and health factors. Serum samples of the participants were used to measure hs‐CRP. To investigate the association between LE8 and hs‐CRP, weighted linear regression, and restricted cubic spline were utilized.ResultsAmong 7229 participants, the average age was 48.03 ± 16.88 years, 3689 (51.2%) were females and the median hs‐CRP was 1.92 (0.81−4.49) mg/L. In adjusted weighted linear regression, a negative correlation was observed between the LE8 score and hs‐CRP. Compared with the low LE8 score, the moderate LE8 score β was −0.533 (−0.646 to −0.420), and the high LE8 score β was −1.237 (−1.376 to −1.097). Health behaviors and health factors were also negatively associated with hs‐CRP. In stratified analyses, the negative correlation between LE8 and hs‐CRP remained consistent across subgroups.ConclusionThere was a negative correlation between LE8 as well as its sub‐indicator scores and hs‐CRP. Maintaining a positive LE8 score may be conducive to lowering the level of hs‐CRP.

中文翻译：

---

Life’s Essential 8 评分与高敏 C 反应蛋白之间的关联：NHANES 2015−2018 的横断面研究

背景早期研究表明生命简单7（LS7）和高敏C反应蛋白（hs-CRP）之间存在负相关，但尚未发现生命基本8（LE8）（LS7的改进版本）与高敏C反应蛋白（hs-CRP）之间存在关联。 CRP.假设本研究利用国家健康和营养检查调查的数据调查了 LE8 和 hs-CRP 之间的关联。方法我们的研究共纳入了 7229 名成年人。 LE8根据美国心脏协会指南进行评分，LE8分为健康行为和健康因素。参与者的血清样本用于测量 hs-CRP。为了研究 LE8 和 hs-CRP 之间的关联，使用了加权线性回归和限制三次样条。结果 在 7229 名参与者中，平均年龄为 48.03 ± 16.88 岁，其中 3689 名 (51.2%) 为女性，hs-CRP 中位数为 1.92 (0.81−4.49) 毫克/升。在调整加权线性回归中，观察到 LE8 评分与 hs-CRP 之间呈负相关。与低LE8分数相比，中等LE8分数β为-0.533（-0.646至-0.420），并且LE8分数较高β为-1.237（-1.376至-1.097）。健康行为和健康因素也与 hs-CRP 呈负相关。在分层分析中，LE8 与 hs-CRP 之间的负相关在各个亚组中保持一致。结论 LE8 及其子指标评分与 hs-CRP 之间存在负相关。维持LE8评分阳性可能有利于降低hs-CRP水平。