According to experimental and clinical studies, status epilepticus (SE) causes neurodegenerative morphological changes not only in the hippocampus and other limbic structures, it also affects the thalamus and the neocortex. In addition, several studies reported atrophy, metabolic changes, and neuronal degeneration in the dorsal striatum. The literature lacks studies investigating potential neuronal damage in the ventral component of the striatopallidal complex (ventral striatum [VS] and ventral pallidum) in SE experimentations. To better understand the development of neuronal damage in the striatopallidal complex associated with SE, the detected neuronal degeneration in the compartments of the VS, namely, the nucleus accumbens (NAc) and the olfactory tubercle (OT), was analyzed. The experiments were performed on Wistar rats at age of 25‐day‐old pups and 3‐month‐old adult animals. Lithium–pilocarpine model of SE was used. Lithium chloride (3 mmol/kg, ip) was injected 24 h before administering pilocarpine (40 mg/kg, ip). This presented study demonstrates the variability of post SE neuronal damage in 25‐day‐old pups in comparison with 3‐month‐old adult rats. The NAc exhibited small to moderate number of Fluoro‐Jade B (FJB)‐positive neurons detected 4 and 8 h post SE intervals. The number of degenerated neurons in the shell subdivision of the NAc significantly increased at survival interval of 12 h after the SE. FJB‐positive neurons were evidently more prominent occupying the whole anteroposterior and mediolateral extent of the nucleus at longer survival intervals of 24 and 48 h after the SE. This was also the case in the bordering vicinity between the shell and the core compartments but with clusters of degenerating cells. The severity of damage of the shell subdivision of the NAc reached its peak at an interval of 24 h post SE. Isolated FJB‐positive neurons were detected in the ventral peripheral part of the core compartment. Degenerated neurons persisted in the shell subdivision of the NAc 1 week after SE. However, the quantity of cell damage had significantly reduced in comparison with the aforementioned shorter intervals. The third layer of the OT exhibited more degenerated neurons than the second layer. The FJB‐positive cells in the young animals were higher than in the adult animals. The morphology of those cells was identical in the two age groups except in the OT.

中文翻译：

---

与成年大鼠相比，癫痫持续状态引起的幼年大鼠大脑腹侧纹状体区室神经元变性

根据实验和临床研究，癫痫持续状态（SE）不仅会导致海马和其他边缘结构的神经退行性形态变化，还会影响丘脑和新皮质。此外，一些研究报告了背侧纹状体的萎缩、代谢变化和神经元变性。文献缺乏调查 SE 实验中纹状体苍白球复合体腹侧部分（腹侧纹状体 [VS] 和腹侧苍白球）潜在神经元损伤的研究。为了更好地了解与 SE 相关的纹状体苍白球复合体神经元损伤的发展，对 VS 区室（即伏隔核 (NAc) 和嗅结节 (OT)）中检测到的神经元变性进行了分析。实验在 25 日龄的幼仔 Wistar 大鼠和 3 个月大的成年大鼠上进行。使用 SE 的锂-毛果芸香碱模型。在给予毛果芸香碱（40 mg/kg，腹膜内）之前24小时注射氯化锂（3毫摩尔/公斤，腹膜内）。本研究表明，与 3 个月大的成年大鼠相比，25 日龄幼鼠 SE 后神经元损伤存在差异。在 SE 间隔后 4 小时和 8 小时检测到 NAc 表现出少量至中等数量的 Fluoro-Jade B (FJB) 阳性神经元。 SE 后 12 小时的存活间隔时，NAc 壳细分中退化神经元的数量显着增加。在 SE 后 24 和 48 小时的较长存活时间间隔内，FJB 阳性神经元明显更突出，占据细胞核的整个前后和中外侧范围。壳和核心室之间的边界附近也是这种情况，但有退化细胞簇。 NAc 外壳细分的损坏严重程度在 SE 后 24 小时内达到峰值。在核心室的腹侧周边部分检测到孤立的 FJB 阳性神经元。 SE 后 1 周，退化的神经元持续存在于 NAc 的壳细分中。然而，与上述较短的间隔相比，细胞损伤的数量显着减少。 OT 的第三层比第二层表现出更多的退化神经元。幼年动物中的 FJB 阳性细胞高于成年动物。除 OT 外，两个年龄组的细胞形态均相同。