We report synthesis of a library of diamino‐terephthalonitrile based single‐benzene fluorophores (SBFs). These SBFs contain a reactive terminal linker group. They open up the possibility of marrying their excellent fluorescent property with various biogenic units, leading to value‐added SBFs. The solvatofluorochromism behavior of these newly synthesized SBFs was also studied. The emission enhances and blue‐shifts in case of non‐polar solvents and vice versa in the polar solvents, implying the environmental sensitivity of these fluorophores. Photostability test was also done to test for the stability of the emission of these fluorophores with time and the fluorophores were found to be stable. We also observed time‐dependent fluorescence enhancement of one of our SBFs in presence of reactive biogenic amines. Overall, the generation of these novel molecules opens up new opportunities towards bioconjugated fluorophores.

中文翻译：

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具有反应性末端基团的绿色荧光二氨基对苯二甲腈用于合成增值荧光团

我们报告了基于二氨基对苯二甲腈的单苯荧光团（SBF）库的合成。这些 SBF 包含反应性末端连接基团。它们开辟了将其优异的荧光特性与各种生物单元相结合的可能性，从而产生增值的SBF。还研究了这些新合成的 SBF 的溶剂化荧光变色行为。在非极性溶剂中，发射增强并发生蓝移，在极性溶剂中反之亦然，这意味着这些荧光团的环境敏感性。还进行了光稳定性测试以测试这些荧光团的发射随时间的稳定性，结果发现荧光团是稳定的。我们还观察到，在存在反应性生物胺的情况下，我们的一种 SBF 会出现时间依赖性荧光增强。总的来说，这些新型分子的产生为生物共轭荧光团开辟了新的机会。