BackgroundUlcerative colitis (UC) refers to an idiopathic chronic inflammatory bowel disease that start with inflammation of the intestinal mucosa. Dietary fiber plays a crucial role in maintaining the normal architecture of the intestinal mucosa. In this study, the protective effect and potential mechanism of soluble dietary fiber from Rosa roxburghii Tratt residue (SDFR) on dextran sulfate sodium (DSS)‐induced UC mice were explored.ResultsThe results revealed that SDFR could ameliorate the body weight loss and pathological injury, improve the structure and crypt destruction in colon in DSS‐induced mice. Moreover, the levels of NO, IL‐1β, TNF‐α, MPO, and protein expression of iNOS and COX‐2 were decreased after administration of SDFR. Notably, nontargeted metabolomics analysis indicated that there were significant differences in 51 potential metabolites in serum between the DSS and control groups. SDFR intervention could regulate aberrant alterations of these metabolites and mitigate UC via regulating metabolic pathway, including arachidonic acid and glycerophospholipid metabolism.ConclusionThis study provides novel evidence that SDFR could be used as a potential modulator to relieve the UC, and also the results provide theoretical basis for the utilization of by‐products in Rosa roxburghii Tratt fruit processing.This article is protected by copyright. All rights reserved.

中文翻译：

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刺梨渣可溶性膳食纤维通过调节血清代谢及NF-κB通路对葡聚糖硫酸钠诱导的小鼠溃疡性结肠炎的保护作用

研究背景溃疡性结肠炎（UC）是指以肠粘膜炎症开始的特发性慢性炎症性肠病。膳食纤维在维持肠粘膜的正常结构中起着至关重要的作用。在这项研究中，可溶性膳食纤维的保护作用和潜在机制刺梨探讨特拉特残留物（SDFR）对右旋糖酐硫酸钠（DSS）诱导的UC小鼠的影响。结果结果显示，SDFR可以改善DSS诱导的小鼠体重减轻和病理损伤，改善结肠结构和隐窝破坏。此外，给予 SDFR 后，NO、IL-1β、TNF-α、MPO 水平以及 iNOS 和 COX-2 蛋白表达降低。值得注意的是，非靶向代谢组学分析表明，DSS 组和对照组之间血清中 51 种潜在代谢物存在显着差异。 SDFR 干预可以调节这些代谢物的异常改变并减轻 UC通过调节代谢途径，包括花生四烯酸和甘油磷脂代谢。结论本研究为SDFR可作为缓解UC的潜在调节剂提供了新的证据，并且结果为副产物的利用提供了理论依据刺梨特拉特水果加工。本文受版权保护。版权所有。