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Effect of cationic lipid concentration on monomer transfer kinetics between zwitterionic lipid vesicles
Journal of Molecular Liquids ( IF 6 ) Pub Date : 2024-04-16 , DOI: 10.1016/j.molliq.2024.124759
L. Bar , M.E. Villanueva , A. Sánchez-Rodríguez , J. Goole , P. Grosfils , P. Losada-Pérez

The kinetics of spontaneous monomer transfer between vesicles consisting of zwitterionic phospholipids is dictated by the difference in desorption rate of lipid monomers from their donor vesicles and the concentration imbalance in the dispersion. In a system with two lipid species with the same headgroup, transfer is asymmetric, and takes place from the population of donor vesicles consisting of shorter chain lipids to acceptor ones of longer chain. Transfer typically proceeds until equilibrium is reached, resulting in populations of vesicles consisting of a binary mixture of both lipid species, whose concentration depends on the number of lipids in the precursor donor and acceptor vesicles before transfer.

中文翻译:

阳离子脂质浓度对两性离子脂质囊泡之间单体转移动力学的影响

由两性离子磷脂组成的囊泡之间自发单体转移的动力学取决于脂质单体从其供体囊泡中解吸速率的差异以及分散体中的浓度不平衡。在具有相同头部基团的两种脂质种类的系统中,转移是不对称的,并且发生从由较短链脂质组成的供体囊泡群到较长链脂质的受体囊泡群体。转移通常进行直至达到平衡,从而产生由两种脂质种类的二元混合物组成的囊泡群体,其浓度取决于转移前前体供体和受体囊泡中的脂质数量。
更新日期:2024-04-16
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