Background/Objective: The association between appendicitis and colon cancer is not yet fully understood. Previous studies have shown contradictory results. Currently, no population-based data from Germany are available with regard to the incidence of colon cancer following appendicitis. This study investigated the association between appendicitis and the incidence of colon cancer in Germany. Methods: In this retrospective cohort study, the incidence of colon cancer was compared for patients with appendicitis and patients without appendicitis, matched for age, sex, index year, average annual consultation frequency, and comorbidity. The aim of the study was to explore the relationship between appendicitis and the incidence of colon cancer. The evaluation was carried out using logistic regression analyses. Results: The study included 49,790 people with and without appendicitis, with a median age of 41 years. During a follow-up period of up to 15 years, 1.04% of cases with appendicitis and 0.60% of cases without appendicitis were newly diagnosed with colon cancer, with some 36.4% of colon cancer cases diagnosed within the first six months after appendicitis. Regression analyses revealed a significant association between appendicitis and colon cancer, particularly in men and in the age groups 41–50 (HR: 10.30; 95% CI: 1.03–43.82) and 18–30 years (HR: 8.17; 95% CI: 1.03–64.58). Conclusions: The present retrospective cohort study suggests an association between appendicitis and the incidence of colon cancer in Germany. Based on our results, we recommend offering a colonoscopy or at least a stool test within 12 months after appendicitis, especially for 18–50-year-olds and >60-year-olds in good general health.

中文翻译：

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结肠癌发病率升高与既往阑尾炎相关：一项基于德国全科医疗数据的回顾性队列研究

背景/目的：阑尾炎和结肠癌之间的关联尚未完全了解。先前的研究显示出相互矛盾的结果。目前，德国没有关于阑尾炎后结肠癌发病率的人口数据。这项研究调查了德国阑尾炎与结肠癌发病率之间的关联。方法：在这项回顾性队列研究中，比较了阑尾炎患者和非阑尾炎患者的结肠癌发病率，并匹配了年龄、性别、索引年份、平均每年就诊频率和合并症。该研究的目的是探讨阑尾炎与结肠癌发病率之间的关系。使用逻辑回归分析进行评估。结果：该研究纳入了 49,790 名患有或未患有阑尾炎的人，中位年龄为 41 岁。在长达15年的随访期间，1.04%的阑尾炎病例和0.60%的非阑尾炎病例新诊断出结肠癌，其中约36.4%的结肠癌病例是在阑尾炎后的前六个月内确诊的。回归分析显示阑尾炎和结肠癌之间存在显着关联，特别是在男性和 41-50 岁年龄组（HR：10.30；95% CI：1.03-43.82）和 18-30 岁（HR：8.17；95% CI： 1.03–64.58）。结论：本回顾性队列研究表明德国阑尾炎与结肠癌发病率之间存在关联。根据我们的结果，我们建议在阑尾炎发生后 12 个月内进行结肠镜检查或至少进行粪便检查，特别是对于一般健康状况良好的 18-50 岁和 60 岁以上的老年人。