Traditional tissue closure methods, such as sutures and staples, can be invasive and lead to postoperative difficulties. Conversely, clinical bioadhesives often exhibit weak adhesion to wet tissue due to an interfacial water barrier. Inspired by the liquid-to-solid hardening mechanism of mussel underwater adhesion, this work introduces an acid-induced adhesive (AIA) with inherent self-hardening capabilities. The AIA, solely composed of poly(thioctic acid) (polyTA), was developed through the acid-induced phase transition from an aq. solution of arginine thioctate. PolyTA was a hydrophobic poly(disulfides) linear polymer with abundant carboxyl groups. This composition enables it to evict the interfacial water, form a large number of hydrogen bonds, and engage in hydrophobic interactions with tissues. The self-hardening of AIA stems from the rearrangement of the hydrophobic polymer main chain, significantly enhancing the cohesion of this bioadhesive. Its lap-shear adhesion strength to wet and underwater porcine skin reached up to approximately 184 and 173 kPa within 10 min, respectively. Beyond its tissue adhesion performance, AIA excelled in leak sealing, on-demand detaching, biodegradation, good biocompatibility, M2-phenotype macrophage polarization regulation, and cell migration promotion. This polyTA-based bioadhesive presents an ideal strategy for biomedical applications.

中文翻译：

---

由动态聚硫辛酸网络实现的可生物降解的水下组织粘合剂

传统的组织闭合方法，例如缝合和钉书钉，可能是侵入性的，会导致术后困难。相反，由于界面水屏障，临床生物粘合剂通常对湿组织表现出较弱的粘合力。受贻贝水下粘附的液固硬化机制的启发，这项工作引入了一种具有固有自硬化能力的酸诱导粘合剂（AIA）。 AIA 仅由聚硫辛酸 (polyTA) 组成，是通过酸诱导水溶液的相变而开发的。硫辛酸精氨酸溶液。 PolyTA 是一种具有丰富羧基的疏水性聚（二硫化物）线性聚合物。这种成分使其能够排出界面水，形成大量氢键，并与组织进行疏水相互作用。 AIA的自硬化源于疏水性聚合物主链的重排，显着增强了这种生物粘合剂的内聚力。其对潮湿和水下猪皮肤的搭接剪切粘合强度在10分钟内分别达到约184和173 kPa。除了其组织粘附性能之外，AIA 在渗漏密封、按需分离、生物降解、良好的生物相容性、M2 表型巨噬细胞极化调节和细胞迁移促进方面也表现出色。这种基于聚TA的生物粘合剂为生物医学应用提供了理想的策略。