The impact of newly detected diabetes mellitus (NDDM) on metabolic parameters and extent of myocardial necrosis in patients with acute coronary syndrome (ACS) is not fully explored. We examined the impact of NDDM on cardiometabolic characteristics and myocardial necrosis in ACS patients. CALLINICUS-Hellas Registry is an ongoing prospective multicenter observational study evaluating the adherence to lipid-lowering therapy (LLT) among ACS patients in Greece. Three groups were created: a) patients with NDDM (abnormal fasting glucose, HbA1c ≥ 6.5 % and no previous history of DM), b) patients without known DM and HbA1c < 6.5 % (non-DM) and c) patients with prior DM. The prevalence of NDDM among 1084 patients was 6.9 %. NDDM patients had lower HDL-C [38 (32–45) vs 42 (36–50) mg/dL] and higher triglycerides levels [144 (104–231) vs 115 (87–152) mg/dL] compared to non-DM patients (p < 0.05). NDDM patients featured both higher body mass index [29.5 (26.4–34.3) vs 27.1 (24.9–29.9) kg/m] and waist circumference [107 (100–114) vs 98 (91–106) cm] compared to non-DM patients (p < 0.05). In addition, NDDM patients had more extensive myocardial necrosis than patients with prior DM. ACS patients with NDDM have an adverse cardiometabolic profile similar to patients with prior DM and have more extensive myocardial insult.

中文翻译：

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新发现的患有急性冠状动脉综合征的糖尿病患者具有与既往糖尿病患者相似的不良心脏代谢特征，并且具有更广泛的缺血性心肌损伤

新发现的糖尿病（NDDM）对急性冠脉综合征（ACS）患者代谢参数和心肌坏死程度的影响尚未得到充分探讨。我们研究了 NDDM 对 ACS 患者心脏代谢特征和心肌坏死的影响。 CALLINICUS-Hellas 登记是一项正在进行的前瞻性多中心观察性研究，旨在评估希腊 ACS 患者对降脂治疗 (LLT) 的依从性。创建了三组：a) NDDM 患者（空腹血糖异常，HbA1c ≥ 6.5% 且既往无糖尿病病史），b) 无已知 DM 且 HbA1c < 6.5%（非糖尿病）的患者，c) 既往有 DM 的患者。 1084 名患者中 NDDM 的患病率为 6.9%。与非糖尿病患者相比，NDDM 患者的 HDL-C 较低 [38 (32–45) vs 42 (36–50) mg/dL]，甘油三酯水平较高 [144 (104–231) vs 115 (87–152) mg/dL] -DM 患者（p < 0.05）。与非 DM 患者相比，NDDM 患者的体重指数 [29.5 (26.4–34.3) vs 27.1 (24.9–29.9) kg/m] 和腰围 [107 (100–114) vs 98 (91–106) cm] 较高患者（p < 0.05）。此外，NDDM 患者比既往 DM 患者有更广泛的心肌坏死。患有 NDDM 的 ACS 患者具有与既往 DM 患者相似的不良心脏代谢特征，并且具有更广泛的心肌损伤。