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Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity
Chemistry & Biodiversity ( IF 2.9 ) Pub Date : 2024-04-18 , DOI: 10.1002/cbdv.202400524
Chengcheng Hui 1 , Shuaibo He 1 , Mengshan Ji 1 , Yuhang Zhang 2 , Haibo Wang 3 , Xiaowei Wang 3 , Tao guo 4
Affiliation  

Baihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine oxidase activity with 20.96% and 22.31% inhibition rates at 50 μg/ml, respectively.

中文翻译:

百合中两种新的苯丙素化合物及其抗单胺氧化酶活性

白鹤是治疗神经系统疾病的常用中药。临床上用百合的球茎作为白鹤。在该研究中,从 L. Brownii 的球茎中分离出两种新的苯丙素化合物,包括 3-O-乙酰基-1-O-咖啡酰甘油 (1) 和 3-O-乙酰基-1-Op-香豆酰甘油 (2)。通过光谱法鉴定它们的结构,并使用酶标记法测定对单胺氧化酶活性的影响。结果表明,1和2具有抗单胺氧化酶活性,在50 μg/ml浓度下抑制率分别为20.96%和22.31%。
更新日期:2024-04-18
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