Abstract: Psychrophilic fungus Pseudogymnoascus sp. OUCMDZ-4032 derived from Antarctica was cultivated under 16 ℃ to produce a new glucolipid compound (1). Its structure was elucidated by analysis of detailed spectroscopic data, acid hydrolysis and 1-phenyl-3-methyl-5-pyrazolone precolumn derivatization, and 13C NMR quantum chemical calculations. Though compound 1 did not show inhibitory activity against bacteria, it can reduce the minimum inhibitory concentration (MIC) of ciprofloxacin against Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli, and Salmonella paratyphi by 1024, 256 and 256-fold. Compound 1 showed potential as a synergistically inhibiting adjuvant in co-administration with antibiotic to enhance antibacterial activities.

中文翻译：

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环丙沙星和新型糖脂联合治疗对革兰氏阴性菌的协同抑制作用

摘要： 嗜冷真菌 Pseudogymnoascus sp.来自南极洲的OUCMDZ-4032在16℃下培养，产生一种新的糖脂化合物(1)。通过分析详细的光谱数据、酸水解和1-苯基-3-甲基-5-吡唑啉酮柱前衍生化以及13C NMR量子化学计算，阐明了其结构。虽然化合物1对细菌没有表现出抑制活性，但它可使环丙沙星对铜绿假单胞菌、大肠杆菌和副伤寒沙门氏菌的最低抑菌浓度（MIC）分别降低1024、256和256倍。化合物 1 显示出作为与抗生素共同给药的协同抑制佐剂以增强抗菌活性的潜力。