Fused deposition modeling (FDM) is a rather new technology in the production of personalized dosage forms. The melting and printing of polymer–active pharmaceutical ingredient (API)—mixtures can be used to produce oral dosage forms with different dosage as well as release behavior. This process is utilized to increase the bioavailability of pharmaceutically relevant active ingredients that are poorly soluble in physiological medium by transforming them into solid amorphous dispersions (ASD). The release from such ASDs is expected to be faster and higher compared to the raw materials and thus enhance bioavailability. Printing directly from powder while forming ASDs from loperamide in Polyvinylalcohol was realized. Different techniques such as a change in infill and the incorporation of sorbitol as a plastisizer to change release patterns as well as a non-destructive way for the determination of API distribution were shown. By measuring the melt viscosities of the mixtures printed, a rheological model for the printer used is proposed.

中文翻译：

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粉末 PVA 片剂的可印刷性评价和关键流变参数的评估

熔融沉积成型（FDM）是个性化剂型生产中一项相当新的技术。聚合物活性药物成分（API）混合物的熔融和印刷可用于生产具有不同剂量和释放行为的口服剂型。该过程用于通过将难溶于生理介质的药物相关活性成分转化为固体无定形分散体（ASD）来提高其生物利用度。与原材料相比，此类 ASD 的释放预计更快、更高，从而提高生物利用度。实现了直接从粉末打印，同时用聚乙烯醇中的洛哌丁胺形成 ASD。展示了不同的技术，例如改变填充物和加入山梨醇作为增塑剂来改变释放模式，以及确定 API 分布的非破坏性方法。通过测量打印混合物的熔体粘度，提出了所用打印机的流变模型。