Acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) often indicates a poor prognosis. This study aimed to investigate the association between the TyG index and the risk of AKI in patients with AMI. Data were taken from the Medical Information Mart for Intensive Care (MIMIC) database. A 1:3 propensity score (PS) was set to match patients in the AKI and non-AKI groups. Multivariate logistic regression analysis, restricted cubic spline (RCS) regression and subgroup analysis were performed to assess the association between TyG index and AKI. Totally, 1831 AMI patients were included, of which 302 (15.6%) had AKI. The TyG level was higher in AKI patients than in non-AKI patients (9.30 ± 0.71 mg/mL vs. 9.03 ± 0.73 mg/mL, P < 0.001). Compared to the lowest quartile of TyG levels, quartiles 3 or 4 had a higher risk of AKI, respectively (Odds Ratiomodel 4 = 2.139, 95% Confidence Interval: 1.382–3.310, for quartile 4 vs. quartile 1, Ptrend < 0.001). The risk of AKI increased by 34.4% when the TyG level increased by 1 S.D. (OR: 1.344, 95% CI: 1.150–1.570, P < 0.001). The TyG level was non-linearly associated with the risk of AKI in the population within a specified range. After 1:3 propensity score matching, the results were similar and the TyG level remained a risk factor for AKI in patients with AMI. High levels of TyG increase the risk of AKI in AMI patients. The TyG level is a predictor of AKI risk in AMI patients, and can be used for clinical management.

中文翻译：

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急性心肌梗死患者甘油三酯葡萄糖与急性肾损伤之间的关联：倾向评分匹配分析

急性心肌梗死（AMI）患者的急性肾损伤（AKI）通常预示着预后不良。本研究旨在探讨 AMI 患者 TyG 指数与 AKI 风险之间的关联。数据取自重症监护医疗信息市场 (MIMIC) 数据库。设置 1:3 的倾向评分 (PS) 以匹配 AKI 和非 AKI 组的患者。进行多变量逻辑回归分析、限制三次样条 (RCS) 回归和亚组分析来评估 TyG 指数与 AKI 之间的关联。总共纳入 1831 名 AMI 患者，其中 302 名（15.6%）患有 AKI。 AKI 患者的 TyG 水平高于非 AKI 患者（9.30 ± 0.71 mg/mL vs. 9.03 ± 0.73 mg/mL，P < 0.001）。与 TyG 水平的最低四分位数相比，四分位数 3 或四分位数分别具有较高的 AKI 风险（优势比模型 4 = 2.139，95% 置信区间：1.382–3.310，对于四分位数 4 与四分位数 1，Ptrend < 0.001）。 TyG水平每增加1个SD，AKI风险增加34.4%（OR：1.344，95% CI：1.150–1.570，P < 0.001）。 TyG 水平与特定范围内人群中 AKI 的风险呈非线性相关。经过1:3倾向评分匹配后，结果相似，TyG水平仍然是AMI患者发生AKI的危险因素。高水平的 TyG 会增加 AMI 患者发生 AKI 的风险。 TyG 水平是 AMI 患者 AKI 风险的预测因子，可用于临床管理。