This case study investigated the impact of SCS on alterations in blood pressure during constant‐load exercise in a female patient with heart failure. Three different SCS frequencies [No SCS (~0 Hz), Low SCS (~100 Hz), and High SCS (~1000 Hz)] with and without ischaemic stimulation of the legs (cuffs) were randomly applied during constant‐load exercise. To determine cardiovascular and ventilatory responses to exercise following SCS frequencies, BP, heart rate (HR), and respiratory gas exchange were measured. This experiment was duplicated in visit 1 and visit 2 with a random application of SCS frequency order and the data were averaged. There were no significant differences among three frequencies with no leg ischaemia. However, High SCS demonstrated lower BP, HR, and respiratory gas exchange relative to No SCS and Low SCS. SCS may be effective in improving cardiovascular and ventilatory responses in HF and high‐frequency stimulation provides more clinical benefit; however, further studies are needed.

中文翻译：

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通过抑制心力衰竭脊髓刺激的传入反馈来减弱心血管对运动的反应

本案例研究调查了 SCS 对患有心力衰竭的女性患者进行恒负荷运动时血压变化的影响。三种不同的 SCS 频率 [无 SCS（~0 赫兹），低SCS（~100 赫兹），以及高SCS(~1000 Hz)]在恒负荷运动期间随机应用有或没有腿部（袖口）缺血刺激。为了确定 SCS 频率后心血管和通气对运动的反应，测量了血压、心率 (HR) 和呼吸气体交换。该实验在访问 1 和访问 2 中重复，随机应用 SCS 频率顺序并对数据进行平均。三种频率无显着差异，无腿部缺血。然而，高SCS与其他人相比，表现出较低的血压、心率和呼吸气体交换无 SCS和低SCS。 SCS 可能有效改善心力衰竭时的心血管和通气反应，并且高频刺激可提供更多临床益处；然而，还需要进一步研究。