During the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15-dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently studied strain of the common pathogenic A. mellea yielded other melleolides, with 5’-O-methylmelledonal (4), melledonal C (5), 10 α-hydroxydihydromelleolide (6) and melledonal (7). The chemical structures were elucidated using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). All compounds were studied for their antimicrobial and cytotoxic effects against a panel of microbes and mammalian cell lines, and the results are also reported.

中文翻译：

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担子菌类蜜环菌和脱蜜菌次生代谢的比较

在我们对担子菌门培养物的次生代谢进行持续研究的过程中，从稀有腐生菌种的培养物中分离出一种名为 10, 15-二羟基二氢蜜环内酯 (1) 的新类萜，以及已知的蜜环菌素 (2) 和阿纳米醇 (3) , 脱热菌。这些是从后者物种中分离出来的第一个次生代谢物。同时研究的常见致病性蜜环菌菌株产生了其他蜜环内酯，包括 5'-O-甲基蜜环内酯 (4)、蜜环内酯 C (5)、10 α-羟基二氢蜜环内酯 (6) 和蜜环内酯 (7)。使用一维和二维核磁共振波谱和高分辨率电喷雾电离质谱（HR-ESI-MS）阐明了化学结构。研究了所有化合物对一组微生物和哺乳动物细胞系的抗菌和细胞毒性作用，并报告了结果。