Disability is a serious health issue that can have a significant impact on both physical and mental health. This study attempted to investigate the relationship between depression, quality of life (QOL), and COVID-19 challenges faced by people with disabilities (PwD) from Saudi Arabia. A structured interview questionnaire to measure QOL (WHOQOL-BREF) and depression (PHQ-9) was used to conduct a cross-sectional study among PwDs in Saudi Arabia. Binary regression analysis was done using SPSS-IBM and predictors for depression, quality of life and COVID-19 challenges were determined. Of the 111 study samples, two-thirds were male (67.6%), with only one-third employed (34.2%). Most of them (70%) reported moderate to severe disability-related difficulties. Only 28.8% of the samples were satisfied with the physical health domain of the quality of life, whereas 31.5%, 44.1%, and 50.5% were satisfied with the psychological, social, and environmental health domains, respectively. Approximately 62% of the participants had been diagnosed with depression. A significantly higher percentage of participants who had not received COVID-19 vaccination were depressed (P = 0.011), whereas the depression rate was lower among those who received three or four doses of vaccination (P = 0.006). Depression is 4.1 times more likely in people with comorbidities, and disability with increased difficulty (OR: 4.266). Furthermore, vaccinated people had a 5.3-fold higher chance of developing satisfactory QOL. Regardless of the type, cause, or duration of disability, the degree of difficulty is a strong predictor of depression and a decrease in quality of life. A multidisciplinary approach is needed to improve the well-being of people with disabilities.

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解读残疾人抑郁症、生活质量和 COVID-19 挑战之间的相关性：沙特阿拉伯的观点

残疾是一个严重的健康问题，可能对身心健康产生重大影响。本研究试图调查沙特阿拉伯残疾人 (PwD) 面临的抑郁症、生活质量 (QOL) 和 COVID-19 挑战之间的关系。使用结构化访谈问卷来衡量生活质量 (WHOQOL-BREF) 和抑郁症 (PHQ-9)，对沙特阿拉伯的残疾人进行了横断面研究。使用 SPSS-IBM 进行二元回归分析，并确定抑郁症、生活质量和 COVID-19 挑战的预测因子。在 111 个研究样本中，三分之二是男性（67.6%），只有三分之一有工作（34.2%）。他们中的大多数（70%）报告了中度至重度残疾相关的困难。只有28.8%的样本对生活质量中的身体健康领域感到满意，而对心理、社会和环境健康领域的满意度分别为31.5%、44.1%和50.5%。大约 62% 的参与者被诊断出患有抑郁症。未接种 COVID-19 疫苗的参与者抑郁症比例明显较高 (P = 0.011)，而接种三剂或四剂疫苗的参与者抑郁率较低 (P = 0.006)。患有合并症和残疾难度增加的人患抑郁症的可能性高出 4.1 倍（OR：4.266）。此外，接种疫苗的人获得满意生活质量的机会高出 5.3 倍。无论残疾的类型、原因或持续时间如何，困难程度都是抑郁和生活质量下降的有力预测因素。需要采取多学科方法来改善残疾人的福祉。