Breast cancer is a leading cause of mortality and the most prevalent form of malignant tumor among women worldwide. Breast cancer cells exhibit an elevated glycolysis and altered glucose metabolism. Moreover, these cells display abnormal glycosylation patterns, influencing invasion, proliferation, metastasis, and drug resistance. Consequently, targeting glycolysis and mitigating abnormal glycosylation represent key therapeutic strategies for breast cancer. This review underscores the importance of protein glycosylation and glucose metabolism alterations in breast cancer. The current research efforts in developing effective interventions targeting glycolysis and glycosylation are further discussed.

乳腺癌是全球女性死亡的主要原因，也是最常见的恶性肿瘤。乳腺癌细胞表现出糖酵解升高和葡萄糖代谢改变。此外，这些细胞表现出异常的糖基化模式，影响侵袭、增殖、转移和耐药性。因此，靶向糖酵解和减轻异常糖基化是乳腺癌的关键治疗策略。这篇综述强调了蛋白质糖基化和葡萄糖代谢改变在乳腺癌中的重要性。进一步讨论了当前针对糖酵解和糖基化开发有效干预措施的研究工作。