Bioelectronics offer unprecedented spatiotemporal resolution in medicine, opening new doors to electronic therapies and monitoring systems. However, the development of bioelectronic medicine requires the construction of a stable interface between a device and tissue. Here, we focus on generating a framework from which to view this interface, specifically for the case of bioelectronic implants. We discuss general criteria that are important to consider when constructing a bioelectronic implant, with a major focus on the structure of the interface as it pertains to tissue. We categorize different mechanical, electrical, and chemical strategies that can be considered in tandem when designing a bioelectronic interface. This perspective aims to provide a useful framework to consider interfacial construction to aid in the development of new areas of bioelectronic medicine using implantable devices.

生物电子学为医学提供了前所未有的时空分辨率，为电子治疗和监测系统打开了新的大门。然而，生物电子医学的发展需要在设备和组织之间构建稳定的界面。在这里，我们专注于生成一个框架来查看该界面，特别是针对生物电子植入物的情况。我们讨论了构建生物电子植入物时需要考虑的重要一般标准，主要关注与组织相关的界面结构。我们对不同的机械、电气和化学策略进行分类，在设计生物电子接口时可以同时考虑这些策略。这一观点旨在提供一个有用的框架来考虑界面构造，以帮助使用可植入设备开发生物电子医学新领域。